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- Title
The GABA[sub A] agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans.
- Authors
Faulhaber, Johannes; Steiger, Axel; Lancel, M.
- Abstract
Abstract Recent studies in the rat demonstrated that systemic administration of muscimol and THIP, both selective GABA[sub A] receptor agonists, elevates slow wave activity in the EEG during non-rapid eye movement (NREM) sleep. In this placebo-controlled study, we assessed the influence of an oral dose of 20 mg THIP on nocturnal sleep in young healthy humans. Compared to placebo, THIP increased slow wave sleep by about 25 min. Spectral analysis of the EEG within NREM sleep revealed significant elevations in the lower frequencies (< 8 Hz) and reductions in the spindle frequency range (Is approximately equal to 10-16 Hz). In accordance with previous findings in the rat, these data imply that GABA[sub A] agonists promote deep NREM sleep, without suppressing REM sleep. These effects are opposite to those induced by agonistic modulators of GABA[sub A] receptors such as benzodiazepines and are at variance with established mechanisms according to which GABA[sub A] agonists and modulatory agonists would have similar effects. The sleep response to GABA[sub A] agonists is highly similar to that evoked by sustained wakefulness, suggesting that GABA[sub A] receptors may be implicated in the homeostatic regulation of sleep.
- Subjects
GABA receptors; ELECTROENCEPHALOGRAPHY; SLOW wave sleep; SPECTRUM analysis; PHYSIOLOGY
- Publication
Psychopharmacology, 1997, Vol 130, Issue 3, p285
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s002130050241