We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Neuroendocrine Tumor, Well Differentiated, of the Breast: A Relatively High-Grade Case in the Histological Subtype.
- Authors
Shogo Tajima; Hajime Horiuchi
- Abstract
Primary neuroendocrine carcinomaof the breast is a rare entity, comprising <1%of breast carcinomas. Described here is the case of a 78-year-oldwomanwho developed an invasive tumor in the left breastmeasuring 2.0 cmx 1.5 cmx 1.2 cm. The tumor was composed of only endocrine elements in the invasive part. It infiltrated in a nested fashion with no tubular formation. Intraductal components were present both inside and outside of the invasive portion. Almost all carcinoma cells consisting of invasive and intraductal parts were positive for synaptophysin and neuron-specific enolase. According to theWorld Health Organization classification 2012, this tumor was subclassified as neuroendocrine tumor, well-differentiated. Among the subgroup, this tumor was relatively high-grade because it was grade 3 tumor with a fewmitotic figures. Vascular and lymphatic permeation and lymph nodemetastases were noted. In the lymph nodes, themorphology of the tumor was similar to the primary site. No distantmetastasis and no relapse was seen for one year after surgery. The prognosis of neuroendocrine carcinomas is thought to beworse than invasive mammary carcinomas, not otherwise specified. Therefore, immunohistochemistry for neuroendocrine markers is important in the routine practice to prevent overlooking neuroendocrine carcinomas.
- Subjects
NEUROENDOCRINE tumors; BREAST cancer; HISTOLOGY; CELL differentiation; SYNAPTOPHYSIN; BIOMARKERS; IMMUNOHISTOCHEMISTRY
- Publication
Case Reports in Pathology, 2013, p1
- ISSN
2090-6781
- Publication type
Article
- DOI
10.1155/2013/204065