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- Title
Absence of mutations in cereblon (CRBN) and DNA damage-binding protein 1 (DDB1) genes and significance for IMiD therapy.
- Authors
Thakurta, A; Gandhi, A K; Waldman, M F; Bjorklund, C; Ning, Y; Mendy, D; Schafer, P; Lopez-Girona, A; Lentzsch, S; Schey, S A; Calle, Y; Chelliah, R; Orlowski, R Z; Madan, A; Avet-Loiseau, H; Chopra, R
- Abstract
The article presents a study focusing sequencing the exons of cereblon (CRBN) with a goal of identifying missense or nonsense mutations with likely functional and clinical consequence. It presents an analysis of immunomodulatory drugs (IMiD)-sensitive as well as isogenic-sensitive or acquired lenalidomide- and/or pomalidomide-resistant multiple myeloma (MM) cell lines. The association of the development of lenalidomide resistance in the ANBL-6 cell line on CRBN mutation is also tackled.
- Subjects
EXONS (Genetics); CELL lines; MULTIPLE myeloma; GENETIC mutation; DNA damage
- Publication
Leukemia (08876924), 2014, Vol 28, Issue 5, p1129
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2013.315