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- Title
Selenium-Supplemented Diet Influences Histological Features of Liver and Kidney in Tilapia (Oreochromis niloticus).
- Authors
Iqbal, Sonia; Atique, Usman; Mughal, Muhammad Sharif; Younus, Muhammad; Rafique, Muhammad Kamran; Haider, Muhammad Sultan; Iqbal, Hafiza Sundas; Sherzada, Shahid; Khan, Tanveer Ali
- Abstract
Selenium is considered as an eco-toxicological paradox owing to its antioxidant and toxic properties. This study aimed at exploring the potential impacts of selenium supplemented in feed on the histology of vital organs of tilapia (Oreochromis niloticus). During this study, neither behavioural abnormalities nor any fish mortalities recorded in fish subjected to different selenium levels during this trial. The results revealed significant histological changes in liver and kidney tissues, mainly linked in a dose-dependent manner. The resultant histological changes exhibited mild or no alterations in fish that consumed the diet having 2 mg Se/kg. However, the intensity of histopathological alterations manifested more in the liver and kidney tissues of fish, having fed on a higher dose of selenium (8 mg Se/kg) as compared to control, 2, and 4 mg Se/kg in the feed. In the case of the liver, there were severe cytoplasmic vacuolations of hepatocytes and central vein dilation, erythrocytes haemolyzed, prominent vascular hypertrophy, and fibrosis of perivascular parts conspicuously noticeable leading to loss of characteristic architecture of hepatic tissues. However, in kidney tissues, renal tubules were seen atrophied and degenerative vacuolar changes in the renal tubular epithelial cells, pyknotic nuclei, as well as a thin layer of fibrous connective tissue (FCT), observed which were swiftly proliferating in peritubular parts of the medulla. In conclusion, selenium incorporated in higher concentrations damaged the vital organs in a dose-dependent manner resulting in histological alterations and proved to be harmful to the fish. However, lower level (2 mg/kg) did not influence or have the least affected histological changes in vital organs.
- Subjects
NILE tilapia; TILAPIA; KIDNEYS; KIDNEY tubules; SELENIUM supplements; LIVER
- Publication
Jordan Journal of Biological Sciences, 2020, Vol 13, Issue 4, p453
- ISSN
1995-6673
- Publication type
Article