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- Title
Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus.
- Authors
Kwon, Oh-Seok; Kim, Donghwa; Kim, Chang-Kwon; Sun, Jeongyoon; Sim, Chung J.; Oh, Dong-Chan; Lee, Sang Kook; Oh, Ki-Bong; Shin, Jongheon
- Abstract
Twelve new sesterterpenes along with eight known sesterterpenes were isolated from the marine sponge Hyrtios erectus collected off the coast of Chuuk Island, the Federated State of Micronesia. Based upon a combination of spectroscopic and computational analyses, these compounds were determined to be eight glycine-bearing scalaranes (1–8), a 3-keto scalarane (9), two oxidized-furan-bearing scalaranes (10 and 11), and a salmahyrtisane (12). Several of these compounds exhibited weak antiproliferation against diverse cancer cell lines as well as moderate anti-angiogenesis activities. The antiproliferative activity of new compound 4 was found to be associated with G0/G1 arrest in the cell cycle.
- Subjects
MICRONESIA; CELL cycle; SPONGES (Invertebrates); CELL lines; CANCER cells; MARINE debris; ISLANDS
- Publication
Marine Drugs, 2020, Vol 18, Issue 6, p253
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md18050253