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- Title
Roxithromycin monotherapy inducing a partial response in a patient with myeloma: a case report.
- Authors
Chai, Kern Y.; Byrne, Anna L.; Morison, Ian M.
- Abstract
<bold>Background: </bold>Clarithromycin is an efficacious treatment for myeloma in combination with other anti-myeloma therapy but not as monotherapy. To date, all studies have focused on a clarithromycin-specific effect rather than a class effect (macrolide) and there is no information on the activity of roxithromycin in myeloma.<bold>Case Presentation: </bold>Here we report an untreated 86-year-old New Zealand European white man with IgA myeloma whose paraprotein decreased by 57%, consistent with a partial response, after a course of roxithromycin for pneumonia. His paraprotein reduced from 46 to 20 g/L while his hemoglobin improved from 97 to 123 g/L after 1 month.<bold>Conclusion: </bold>Additional investigations should be considered to elucidate the therapeutic effect of roxithromycin in myeloma.
- Subjects
CLARITHROMYCIN; TREATMENT effectiveness; ANTINEOPLASTIC agents; IMMUNOGLOBULIN A; THERAPEUTICS; ANTIBIOTICS; ERYTHROMYCIN; MULTIPLE myeloma; PNEUMONIA; PHARMACODYNAMICS
- Publication
Journal of Medical Case Reports, 2018, Vol 12, Issue 1, pN.PAG
- ISSN
1752-1947
- Publication type
journal article
- DOI
10.1186/s13256-018-1636-9