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- Title
The hypoglycemic effect of Juglans regia leaves aqueous extract in diabetic patients: A first human trial.
- Authors
Hosseini, Saeed; Huseini, Hasan Fallah; Larijani, Bagher; Mohammad, Kazem; Najmizadeh, Alireza; Nourijelyani, Keramt; Jamshidi, Leila
- Abstract
Background: Juglans regia L. (J. regia ) is one of the medicinal plants traditionally used for treatment of diabetes in Iranian medicine. The effect of this plant has already been investigated on animal models; however, this is the first study conducted on human subjects. The aim of this study is to investigate the hypoglycemic effect of J. regia leaves aqueous extract in type 2 diabetes patients. Fifty eight Iranian male and female patients with type 2 diabetes were enrolled. The patients were randomly allocated into two groups. One group (n = 30) received J. regia leaves extract while the other group (n = 28) received placebo. Fasting blood samples were collected at the beginning of the study and after two months for determination of HbA1c and blood glucose level as a main outcome and insulin, SGOT, SGPT, and ALP level as secondary outcome. Results: Our analysis showed that serum fasting HbA1C and blood glucose levels were significantly decreased and the insulin level was increased in patients in the J. regia arm. Conclusions: The results indicate that J. regia aqueous extract favorably affects blood levels of glucose, insulin and HbA1C in type 2 diabetic patients.
- Subjects
IRAN; THERAPEUTIC use of plant extracts; ASPARTATE aminotransferase; DIABETES; GLUCOSE; GLYCOSYLATED hemoglobin; HYPOGLYCEMIC agents; LEAVES; RESEARCH funding; WALNUT; ALANINE aminotransferase; RANDOMIZED controlled trials
- Publication
DARU: Journal of Pharmaceutical Sciences, 2014, Vol 22, p1
- ISSN
1560-8115
- Publication type
Article
- DOI
10.1186/2008-2231-22-19