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- Title
Homogeneous electrocatalytic oxidation of captopril by iodide and its application to pharmaceutical analysis.
- Authors
Jalali, Fahimeh; Bahramipur, Hossein
- Abstract
Potassium iodide was used as a homogeneous electrocatalyst for the oxidation of captopril. Cyclic voltammetry and chronoamperometry were used in kinetic studies. The diffusion coefficient and catalytic rate constant were calculated to be 4.94 × 10 cm s and 1.87 × 10 M s, respectively. Linear sweep voltammetry was applied to quantitative determination of captopril; a linear calibration curve was obtained in the range of 4.0-500 μM of captopril with a limit of detection of 0.84 μM and a sensitivity of 0.035 A M. The method was applied to the determination of the drug in its tablets and validation methods showed that the results were quite satisfactory.
- Subjects
HOMOGENEOUS catalysis; ELECTROCATALYSIS; OXIDATION; CAPTOPRIL; POTASSIUM iodide; DRUGS; CYCLIC voltammetry; QUANTITATIVE chemical analysis
- Publication
Journal of the Iranian Chemical Society, 2012, Vol 9, Issue 6, p889
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/s13738-012-0105-4