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- Title
Genome assembly and haplotyping with Hi-C.
- Authors
Korbel, Jan O; Lee, Charles
- Abstract
The article focuses on improvements inn genome sequencing by using information on long range chromatin interactions using Hi-C method for studying three dimensional folding of genomes. The topics discussed include a computational approach LACHESIS fro pairing different types of DNA sequencing data, use of single nucleotide polymorphisms (SNP) and use of proximity ligation method for identifying long range DNA sequences.
- Subjects
HAPLOTYPES; NUCLEOTIDE sequence; DNA fingerprinting; GENOMICS; MOLECULAR structure of chromatin
- Publication
Nature Biotechnology, 2013, Vol 31, Issue 12, p1099
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt.2764