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- Title
Non-canonical WNT signalling in the lung.
- Authors
Changgong Li; Bellusci, Saverio; Borok, Zea; Minoo, Parviz
- Abstract
The role of WNT signalling in metazoan organogenesis has been a topic of widespread interest. In the lung, while the role of canonical WNT signalling has been examined in some detail by multiple studies, the non-canonical WNT signalling has received limited attention. Reliable evidence shows that this important signalling mechanism constitutes a major regulatory pathway in lung development. In addition, accumulating evidence has also shown that the non-canonical WNT pathway is critical for maintaining lung homeostasis and that aberrant activation of this pathway may underlie several debilitating lung diseases. Functional analyses have further revealed that the non-canonical WNT pathway regulates multiple cellular activities in the lung that are dependent on the specific cellular context. In most cell types, non-canonical WNT signalling regulates canonical WNT activity, which is also critical for many aspects of lung biology. This review will summarize what is currently known about the role of noncanonical WNT signalling in lung development, homeostasis and pathogenesis of disease.
- Subjects
WNT proteins; CELLULAR signal transduction; MORPHOGENESIS; HOMEOSTASIS; PATHOLOGICAL physiology
- Publication
Journal of Biochemistry, 2015, Vol 158, Issue 5, p355
- ISSN
0021-924X
- Publication type
Article
- DOI
10.1093/jb/mvv081