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- Title
Transient Expression of Bone Morphogenic Protein-2 in Acute Liver Injury by Carbon Tetrachloride.
- Authors
Nakatsuka, Ryusuke; Taniguchi, Makoto; Hirata, Mitsuhi; Shiota, Goshi; Sato, Kenzo
- Abstract
Acute liver injury induced by administration of carbon tetrachloride (CCl4) was shown to be a model of wound-repair in rat liver. Albumin gene expression was significantly reduced at 24 h post injection with CCl4, but recovered at 48 h. We also observed significant and transient expression of bone morphogenic protein-2 (BMP-2) at 6-24 h post treatment. This expression was also shown with depletion of Kupffer cell by GdCl3, and immunostaining with anti-BMP-2 antibody showed BMP-2-producing cells interspersed in intralobular spaces of injured liver. These observations suggest that BMP-2 secreted from oval-like cells plays important roles in the wound healing response of injured liver.
- Subjects
LIVER injuries; CARBON tetrachloride; GENE expression; PROTEINS; BIOCHEMISTRY
- Publication
Journal of Biochemistry, 2007, Vol 141, Issue 1, p113
- ISSN
0021-924X
- Publication type
Article
- DOI
10.1093/jb/mvm012