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- Title
Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2.
- Authors
YIMING LIANG; MIN HUANG; JIANWEN LI; XINLIN SUN; XIAODAN JIANG; LIANGPING LI; YIQUAN KE
- Abstract
Glioblastomas (GBMs) are the most common and aggressive malignant primary brain tumors found in humans. In high-grade gliomas, vasculogenic mimicry (VM) is often detected. VM is the formation of de novo vascular networks by highly invasive tumor cells, instead of endothelial cells. An understanding of the mechanisms of VM formation will contribute to the targeted therapy of GBMs. In the present study, the efficacy of curcumin (CCM) on VM formation and its mechanisms were investigated. It was found that CCM inhibits the VM formation, proliferation, migration and invasion of human glioma U251 cells in a dose-dependent manner. Furthermore, CCM downregulated the protein and mRNA expression of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2, indicating that CCM may function through these factors for the inhibition of VM formation. These data provide novel insights into the use of CCM to antagonize VM, and may contribute to the angiogenesis-targeted therapy of malignant glioma.
- Subjects
CURCUMIN; ERYTHROPOIETIN; LIVER cancer; METALLOPROTEINASES; PHOSPHOINOSITIDES; GLIOBLASTOMA multiforme; BRAIN tumors; ENDOTHELIAL cells
- Publication
Oncology Letters, 2014, Vol 8, Issue 4, p1849
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2014.2401