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- Title
Adoptive Transfer of Delayed-Type Hypersensitivity to Sendai Virus.
- Authors
Ertl, H. C. J.
- Abstract
The intrathymic versus extrathymic influences on H-2-restriction specificity of K,D- and I-region-restricted Sendai virus-immune T lymphocytes, which mediate a delayed-type hypersensitivity response in vivo, were investigated. K,D- and I-region-restricted Td lymphocytes of P1→F1 and F1→P1 fetal liver chimeras showed preference but no absolute restriction for the P1 haplotype. T effector lymphocytes of thymic chimeras expressed a slightly higher degree of restriction for the haplotype of the thymus graft than F1→P1 chimeras, which might reflect the activity of T lymphocytes of thymic origin. The lack of absolute restriction of both K,D- and I-region-restricted Td lymphocytes to the haplotype the thymus suggests an additional pathway of T-cell maturation.
- Subjects
DELAYED hypersensitivity; ALLERGIES; SENDAI virus; LYMPHOCYTES; LEUCOCYTES; T cells; ENDOCRINE glands; LYMPHOID tissue; THYMUS
- Publication
Scandinavian Journal of Immunology, 1981, Vol 14, Issue 3, p257
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1981.tb00562.x