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- Title
The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis
- Authors
Can, Ilknur Haberal; Ceylan, Kursat; Caydere, Muzaffer; Samim, Ethem Erdal; Ustun, Huseyin; Karasoy, Durdu Sertkaya
- Abstract
Objectives: To investigate the expression and clinical significance of MMP-2, MMP-7, MMP-9, and TIMP-1 in patients with nasal polyposis (NP) and chronic rhinosinusitis (CRS). Study Design: Prospective study. Subjects and Methods: This study involved 54 patients. There were three groups: nasal polyposis group, chronic rhinosinusitis group, and control group. Specimens were collected during endoscopic sinus surgery. Each sample was immunohistochemically examined. Results: Expression of MMP-2 was found significantly increased in NP, whereas MMP-7 expression was found significantly increased in CRS (P < 0.001). TIMP-1 was significantly high in control group compared to CRS and NP (P < 0.001 and P = 0.002, respectively). Conclusions: Different regulation type of activation of MMPs has been found in these two diseases. If MMP-2 expression is intense in the mucosa, then this ends with polyp formation; if MMP-7 expression is intense, it ends with CRS or stays as CRS.
- Subjects
SINUSITIS; POLYPS; NASAL tumors; METALLOPROTEINASES; MUCOUS membranes; CHRONICALLY ill; PATIENTS
- Publication
Otolaryngology-Head & Neck Surgery, 2008, Vol 139, Issue 2, p211
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2008.04.032