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- Title
Aberrant T-cell antigen expression in B lymphoblastic leukaemia.
- Authors
Hussein, Shafinaz; Gill, Kamraan Z.; Sireci, Anthony N.; Colovai, Adriana I.; Small, Tania; Emmons, Foxwell N.; Murty, Vundavalli V.; Bhagat, Govind; Alobeid, Bachir
- Abstract
Summary B lymphoblastic leukaemia (B-ALL) cells are characterized by the expression of various B-cell antigens. Expression of T/Natural Killer-cell antigens, however, has rarely been reported in B-ALL (TAg+ B-ALL), and the significance of this aberrant antigen expression is unclear. We thus analysed the frequency of TAg+ B-ALL at our institution and investigated its significance in the context of immunophenotypes, cytogenetic/molecular findings, and prognosis. We reviewed 134 consecutive cases of B-ALL and found 18 cases (13·4%) of TAg+ B-ALL. The most common aberrant T-cell antigens expressed were CD2, CD5, and CD7 at equivalent rates (each in six cases), CD4 (two cases), and CD56 (three cases). Adverse cytogenetic abnormalities were seen in a significantly larger proportion of the TAg+ cases (72·2%) than the TAg− cases (32·2%; P = 0·003). Multivariate Cox-regression analysis showed that the risk of relapse over time was higher in the TAg+ cases, independent of high risk status (based on age and white blood cell count) and the presence of adverse cytogenetic abnormalities (hazard ratio = 2·256, P = 0·065). These findings suggest that T-cell antigen expression in B-ALL may be an independent predictor of poor prognosis, and a useful marker to identify patients at increased risk for relapse and for harbouring adverse cytogenetic abnormalities.
- Subjects
LYMPHOBLASTIC leukemia; IMMUNITY; IMMUNOGLOBULINS; ANTIGENS; LEUCOCYTES
- Publication
British Journal of Haematology, 2011, Vol 155, Issue 4, p449
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2011.08870.x