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- Title
Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma.
- Authors
Forrest, Matthew S.; Skibola, Christine F.; Lightfoot, Tracy J.; Bracci, Paige M.; Willett, Eleanor V.; Smith, Martyn T.; Holly, Elizabeth A.; Roman, Eve
- Abstract
Genetic variation in innate immunity may alter host-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population-based case-control studies of NHL from the San Francisco Bay Area (308 cases, 684 controls) and UK (596 cases, 758 controls). The caspase recruitment domain-containing protein 1007fs homozygote variant was positively associated with NHL risk (odds ratios (OR) = 3·1, 95% confidence intervals (CI) 1·1–8·8), whereas the toll-like receptor 4 1063A>G variant allele was inversely associated with diffuse large cell lymphoma (OR = 0·67, 95% CI 0·45–0·99). These results suggest that variation in innate immune genes may alter NHL susceptibility.
- Subjects
NATURAL immunity; IMMUNE response; LYMPHOMAS; GENETIC polymorphisms; GENES; HYPOTHESIS; HODGKIN'S disease
- Publication
British Journal of Haematology, 2006, Vol 134, Issue 2, p180
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2006.06141.x