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- Title
Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia.
- Authors
Harrison, Christine J.; Moorman, Anthony V.; Broadfield, Zoë J.; Cheung, Kan L.; Harris, Rachel L.; Jalali, G. Reza; Robinson, Hazel M.; Barber, Kerry E.; Richards, Sue M.; Mitchell, Christopher D.; Eden, Tim O. B.; Hann, Ian M.; Hill, Frank G. H.; Kinsey, Sally E.; Gibson, Brenda E. S.; Lilleyman, John; Vora, Ajay; Goldstone, Anthony H.; Franklin, Ian M.; Durrant, Jill
- Abstract
This study of children and adults with acute lymphoblastic leukaemia (ALL) is the largest series of patients with hypodiploidy (<46 chromosomes) yet reported. The incidence of 5% was independent of age. Patients were subdivided by the number of chromosomes; near-haploidy (23–29 chromosomes), low hypodiploidy (33–39 chromosomes) and high hypodiploidy (42–45 chromosomes). The near-haploid and low hypodiploid groups were characterized by their chromosomal gains and a doubled hyperdiploid population. Structural abnormalities were more frequent in the low hypodiploid group. Near-haploidy was restricted to children of median age 7 years (range 2–15) whereas low hypodiploidy occurred in an older group of median age 15 years (range 9–54). Patients with 42–45 chromosomes were characterized by complex karyotypes involving chromosomes 7, 9 and 12. The features shared by the few patients with 42–44 chromosomes and the large number with 45 justified their inclusion in the same group. Survival analysis showed a poor outcome for the near-haploid and low hypodiploid groups compared to those with 42–45 chromosomes. Thus cytogenetics, or at least a clear definition of the modal chromosome number, is essential at diagnosis in order to stratify patients with hypodiploidy into the appropriate risk group for treatment.
- Subjects
LYMPHOBLASTIC leukemia; JUVENILE diseases; PATIENTS; CHROMOSOMES; HAPLOIDY; KARYOTYPES
- Publication
British Journal of Haematology, 2004, Vol 125, Issue 5, p552
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2004.04948.x