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- Title
Involvement of Fcγ receptor polymorphism in the therapeutic response of idiopathic thrombocytopenic purpura.
- Authors
Fujimoto, Tetsuro‐Takahiro; Inoue, Maki; Shimomura, Takeshi; Fujimura, Kingo
- Abstract
Clearance of autoantibody-sensitized platelets through Fcγ receptors on phagocytic cells is one of the main mechanisms of thrombocytopenia in idiopathic thrombocytopenic purpura (ITP). We examined the FcγRIIA-131R/H and FcγRIIIA-158V/F polymorphisms in 104 adult chronic ITP patients, and in 59 healthy control subjects using polymerase chain reaction-based allele-specific restriction analysis. The frequency of FcγRIIA genotypes (131H/H, H/R, R/R) was not significantly different between patients and controls, and did not correlate with the responsiveness to treatment. In contrast, among FcγRIIIA genotypes, frequency of 158F/F homotype was smaller in ITP (P < 0·05). Furthermore, in FcγRIIIA-158V/V homotype, the complete remission (CR) rate with medication (treatment with corticosteroid or other immunosuppressive agents) was significantly higher (60%) than that in 158V/F (10%) or 158V/F plus 158F/F, (P < 0·01, P < 0·05). Conversely, the CR rate after splenectomy in 158F/F and 158V/F types (64·3% and 54·6%) was higher than in 158V/V (25%). Our results indicate that the polymorphism of FcγRIIIA, but not FcγRIIA, influences the response to treatment in ITP.
- Subjects
THROMBOPENIC purpura; GENETIC polymorphisms; THERAPEUTICS
- Publication
British Journal of Haematology, 2001, Vol 115, Issue 1, p125
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2001.03109.x