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- Title
A Common Polymorphism in the Interleukin 8 Gene Promoter Is Associated with Clostridium difficile Diarrhea.
- Authors
Zhi-Dong Jiang; DuPont, Herbert L.; Garey, Kevin; Price, Margaret; Graham, Gail; Okhuysen, Pablo; Thanh Dao-Tran; LaRocco, Mark
- Abstract
OBJECTIVE: Mucosal interleukin 8 (IL-8) and neutrophil recruitment are central to the pathogenesis of Clostridium difficile (CD) toxin-induced diarrhea (CDD). We hypothesized that like other inflammatory mucosal infections, susceptibility to CDD would relate to genetically determined variations in the production of IL-8. METHODS: Fecal IL-8 production and single nucleotide polymorphism (SNP) frequency in the −251 region of the IL-8 gene were determined in hospitalized patients: 42 with CDD, 42 with CD-negative diarrhea, and 41 without diarrhea. Cases and controls were matched by age, length of hospital stay, comorbidity, and receipt of antibiotics. RESULTS: An association was found between the IL-8 −251 A/A allele and occurrence of CDD, 39% versus 16% (OR = 3.26, 95% CI 1.09–9.17) and 17% (OR = 5.50, 95% CI 1.22–24.8) for the two control groups. Comparing results by IL-8 genotype for the CDD cases, median and mean fecal IL-8 levels were significantly higher for the −251 A/A genotype ( p= 0.03 for median and 0.001 for mean). CONCLUSIONS: These studies indicate a common SNP in the IL-8 gene is associated with increased susceptibility to CDD and with increased fecal IL-8 in diarrheal stools.
- Subjects
UNITED States; CLOSTRIDIOIDES difficile; INTESTINAL diseases; DIARRHEA; INFLAMMATORY bowel diseases; NUCLEOTIDE sequence; ANTIBIOTICS
- Publication
American Journal of Gastroenterology (Springer Nature), 2006, Vol 101, Issue 5, p1112
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2006.00482.x