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- Title
Lactobacillus Plantarum CGMCC8198-Fermented Milk Inhibits Melanogenesis in B16F10 Melanoma Cells.
- Authors
Cai-Jiao ZHANG; Li-Juan PAN; Wen-Han LU; Hao ZHOU; Nan WANG; Tong-Cun ZHANG; Xue-Gang LUO
- Abstract
Abnormal accumulation of melanin causes unaesthetic hyperpigmentation. Many studies suggest that yogurt have some effects of antioxidant and anti-aging. In this study, the antioxidant and melanogenesis-inhibitory activity of fermented milk supernatant (FMS) prepared by Lactobacillus plantarum CGMCC8198, a novel probiotics strain, were detected. The results in both ABTS and DPPH assay showed that FMS exhibited markedly antioxidant effect. Melanin production was significantly reduced by FMS, while the survival of cells was not affected. Furthermore, FMS reduced the activity of cellular tyrosinase hut had no effect on tyrosinase itself, and the results of RT-PCR, Western blot and immunocytochemistry demonstrated that FMS could inhibit the transcription and expression of tyrosinase, TRP-1, TRP-2 and MITF, and these effects were mainly depended on heated-resistant macromolecule substances. Our results suggested that Lactobacillus plantarum CGMCC8198-Fermented Milk could be a good candidate for antioxidant and treating hyperpigmentation disorders and could also be used as a cosmetic whirening agent.
- Publication
Food Science & Technology Research, 2017, Vol 23, Issue 5, p669
- ISSN
1344-6606
- Publication type
Article
- DOI
10.3136/fstr.23.669