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- Title
Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population.
- Authors
Hemissi, Imen; Ayed, Haroun; Naimi, Zeineb; Meddeb, Khedija; Ayadi, Mouna; Zouari, Skander; Zaghbib, Selim; Talbi, Emna; Chebil, Mohamed; Ouerhani, Slah
- Abstract
Background: NAD (P) H: quinone oxidoreductase (1) (NQO1‐HGNC: 2874) and myeloperoxidase (MPO‐HGNC: 7218) are two enzymes involved in phase II of the xenobiotic metabolism pathway. Methods: In this study, a case–control analysis was conducted to investigate the relationship between genetic variations in the NQO1(C609T, rs1800566; IVS1‐27 C >G, rs689452) and MPO(G463A, rs2333227) genes and the risk for bladder cancer among Tunisian population. Results: We have found that the MPO 463GA genotype was associated with a decreased risk of developing bladder cancer (p = 0.049; OR = 0.696; 95% CI 0.484–0.999). In contrast, we have found that the NQO1 609CT genotype could increase the risk of bladder cancer patients (p = 0.0039; OR = 1.454; 95% CI = 1.017–2.078). Moreover, patients with "NQO1 609 CT/IVS1‐27 CG" genotype show a 2.180‐fold increasing risk for developing bladder cancer in comparison to the control group with wild genotype. This OR is estimated at 5.6‐fold in smokers patients with "NQO1 609 CT/IVS1‐27 CG" genotype. Lastly, study findings suggest that the NQO1 IVS‐27 *CG genotype (rs689452) is associated with a risk of progression to muscle invasive bladder cancer. Conclusion: Our study suggests that environmental risk factors in association to NQO1 genotypes (NQO1 609 CT/IVS1‐27 CG) play an important role in the development of bladder cancer in Tunisian population. The present study suggests that diplotypes of the NQO1 gene play an important role in the development of bladder cancer. There is also an additive interaction between smoking, exposition to professional risk factors, and polymorphisms in the NQO1 gene for the risk development of bladder cancer in Tunisian population.
- Subjects
DISEASE risk factors; BLADDER cancer; XENOBIOTICS; GENETIC variation; CANCER invasiveness; CARCINOGENESIS
- Publication
Molecular Genetics & Genomic Medicine, 2021, Vol 9, Issue 11, p1
- ISSN
2324-9269
- Publication type
Article
- DOI
10.1002/mgg3.1819