We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Metabolomic Effects of Tripeptide Gut Hormone Infusion Compared to Roux-en-Y Gastric Bypass and Caloric Restriction.
- Authors
Jones, Ben; Sands, Caroline; Alexiadou, Kleopatra; Minnion, James; Tharakan, George; Behary, Preeshila; Ahmed, Ahmed R.; Purkayastha, Sanjay; Lewis, Matthew R.; Bloom, Stephen; Li, Jia V.; Tan, Tricia M.
- Abstract
Context: The gut-derived peptide hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY) are regulators of energy intake and glucose homeostasis and are thought to contribute to the glucose-lowering effects of bariatric surgery. Objective: To establish the metabolomic effects of a combined infusion of GLP-1, OXM, and PYY (tripeptide GOP) in comparison to a placebo infusion, Roux-en-Y gastric bypass (RYGB) surgery, and a very low-calorie diet (VLCD). Design and Setting: Subanalysis of a single-blind, randomized, placebo-controlled study of GOP infusion (ClinicalTrials.gov NCT01945840), including VLCD and RYGB comparator groups. Patients and Interventions: Twenty-five obese patients with type 2 diabetes or prediabetes were randomly allocated to receive a 4-week subcutaneous infusion of GOP (n = 14) or 0.9% saline control (n = 11). An additional 22 patients followed a VLCD, and 21 underwent RYGB surgery. Main Outcome Measures: Plasma and urine samples collected at baseline and 4 weeks into each intervention were subjected to cross-platform metabolomic analysis, followed by unsupervised and supervised modeling approaches to identify similarities and differences between the effects of each intervention. Results: Aside from glucose, very few metabolites were affected by GOP, contrasting with major metabolomic changes seen with VLCD and RYGB. Conclusions: Treatment with GOP provides a powerful glucose-lowering effect but does not replicate the broader metabolomic changes seen with VLCD and RYGB. The contribution of these metabolomic changes to the clinical benefits of RYGB remains to be elucidated.
- Subjects
GASTROINTESTINAL hormones; GASTRIC bypass; PEPTIDE hormones
- Publication
Journal of Clinical Endocrinology & Metabolism, 2022, Vol 107, Issue 2, pe767
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgab608