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- Title
Increasing C-reactive protein levels in a patient with glioblastoma with lymph node metastasis: a case report.
- Authors
Kanemitsu, Takuya; Furuse, Motomasa; Kuwabara, Hiroko; Yagi, Ryokichi; Hiramatsu, Ryo; Kameda, Masahiro; Nonoguchi, Naosuke; Kawabata, Shinji; Takami, Toshihiro; Arai, Motohiro; Wanibuchi, Masahiko
- Abstract
Background: Glioblastoma usually recurs locally and extracranial metastases are rare. Most patients with extracranial metastases experience recurrence of the primary intracranial tumor. Lymph node metastases are often detected based on lymphadenopathy or symptoms caused by other metastatic sites. Case presentation: Herein, we report a case of glioblastoma with lymph node metastasis in which the patient was asymptomatic but exhibited gradually increasing C-reactive protein levels prior to becoming febrile 9 months after the initial C-reactive protein increase. Diagnosis of lymph node metastasis that was delayed because the patient had a fever of unknown origin, no signs of infection, and the primary intracranial tumor did not recur. Chest computed tomography indicated supraclavicular, mediastinal, and hilar lymphadenopathy, and biopsy identified lymph node metastasis of glioblastoma. This is the fifth reported case of lymph node metastasis without intracranial recurrence. Conclusions: C-reactive protein levels may be a diagnostic marker for lymph node metastasis in patients with glioblastoma. Further evaluation is needed to elucidate the role of CRP in glioblastoma with lymph node metastasis.
- Subjects
LYMPHATIC metastasis; C-reactive protein; LYMPHADENITIS; GLIOBLASTOMA multiforme; INTRACRANIAL tumors; ASYMPTOMATIC patients
- Publication
BMC Neurology, 2023, Vol 23, Issue 1, p1
- ISSN
1471-2377
- Publication type
Article
- DOI
10.1186/s12883-023-03402-4