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- Title
Modulation of Clopidogrel Pharmacodynamic Response.
- Authors
Goodsaid, Federico M.
- Abstract
The article discusses a study conducted by N. A. Farid et al. about the uncertainty in the drug-drug interaction between clopidogrel and lipophilic statins. Under the study, measurements of the plasma concentrations of the active metabolite of thienopyridine clopidogrel as well as the pharmacodynamic response to the drug were taken. The study affirms that there are differences in the drug-drug interactions of clopidogrel and prasugrel with ketoconazole. It adds that cytochrome P450 (CYP) 3A4 inhibitors have minimal effect on drug responses.
- Subjects
DRUG interactions; ANTICOAGULANTS; STATINS (Cardiovascular agents); DRUG side effects; PHARMACODYNAMICS; METABOLITES; KETOCONAZOLE; CYTOCHROME P-450
- Publication
Pharmacotherapy, 2008, Vol 28, Issue 12, p1423
- ISSN
0277-0008
- Publication type
Article
- DOI
10.1592/phco.28.12.1423