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- Title
The target sign in colorectal liver metastases: an atypical Gd-EOB-DTPA "uptake" on the hepatobiliary phase of MR imaging.
- Authors
Granata, Vincenza; Catalano, Orlando; Fusco, Roberta; Tatangelo, Fabiana; Rega, Daniela; Nasti, Guglielmo; Avallone, Antonio; Piccirillo, Mauro; Izzo, Francesco; Petrillo, Antonella
- Abstract
<bold>Purpose: </bold>To describe the MRI findings in colorectal cancer liver metastases using gadoxetic acid (Gd-EOB-DTPA), with special emphasis on the target feature seen on the hepatobiliary phase.<bold>Material and Methods: </bold>The medical records of 45 colorectal cancer patients with an overall number of 150 liver metastases were reviewed. All patients underwent Gd-EOB-DTPA-enhanced MRI before any kind of treatment. We retrospectively evaluated, for each lesion, the signal intensity on the T1-weighted, T2-weighted, and diffusion-weighted images. Additionally, the enhancement pattern during the arterial-, portal-, equilibrium-, and hepatobiliary-phase was assessed. Fourteen lesions had a pathological correlation.<bold>Results: </bold>Lesions size was 5-40 mm (mean 15 mm). All metastases were hypointense on T1-w imaging. Ninety-nine lesions (66%) had a central area of very high signal intensity on T2-w imaging. Fifty-one metastases (34%) were hyperintense on the T2-w images. In DWI, all lesions had a restricted diffusion. The mean ADC value was 1.31 × 10(-3) mm(2)/s (range 1.10-1.45 × 10(-3) mm(2)/s). During the arterial-phase imaging, 61 lesions (41%) showed a rim enhancement, while 89 lesions (59%) appeared as hypointense. All lesions had low signal intensity in the portal and equilibrium phase. Thirty-nine percent of the lesions also showed an enhancing rim on the portal-phase images. During the hepatobiliary phase, 80 lesions (53.3%) were hypointense, while 70 lesions (46.7%) had a target appearance.<bold>Conclusion: </bold>A number of metastases show an atypical contrast medium uptake during the hepatobiliary phase of gadoxetic acid-enhanced MRI, consisting in a target appearance.
- Subjects
BILIARY tract; COLON tumors; DIAGNOSTIC imaging; LIVER; LIVER tumors; MAGNETIC resonance imaging; RECTUM tumors; CONTRAST media; RETROSPECTIVE studies; SECONDARY primary cancer
- Publication
Abdominal Imaging, 2015, Vol 40, Issue 7, p2364
- ISSN
0942-8925
- Publication type
journal article
- DOI
10.1007/s00261-015-0488-7