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- Title
Diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration to assess tumor-programmed cell death ligand-1 expression in mediastinal lymph nodes metastasized from non-small cell lung cancer.
- Authors
Mineura, Katsutaka; Hamaji, Masatsugu; Yoshizawa, Akihiko; Nakajima, Naoki; Kayawake, Hidenao; Tanaka, Satona; Yamada, Yoshito; Yutaka, Yojiro; Nakajima, Daisuke; Ohsumi, Akihiro; Menju, Toshi; Chen-Yoshikawa, Toyofumi F.; Date, Hiroshi
- Abstract
Purpose: We investigated the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to evaluate programmed cell death ligand-1 (PD-L1) expression in patients with advanced non-small cell lung cancer (NSCLC). Methods: A retrospective chart review of patients who underwent EBUS-TBNA between April 2017 and April 2019 was conducted. Among patients diagnosed with NSCLC, we investigated the rate of successful evaluation of tumor PD-L1 expression, compared the relevant factors between patients with evaluable and those with unevaluable PD-L1 expression, and examined the response to immune checkpoint inhibitors (ICIs) after EBUS-TBNA. Results: Of the 40 patients assessed, 32 (80%) had evaluable PD-L1 expression. Patients with evaluable PD-L1 expression were older than those with unevaluable PD-L1 expression (p = 0.017), and we noted a tendency for a larger diameter of the biopsied lymph node (p = 0.12). The response rate to ICIs was 100% in patients with a tumor proportion score (TPS) ≥ 50%, 33% in those with a TPS 1–49%, and 0% in those with a TPS < 1%. Conclusion: The diagnostic yield of EBUS-TBNA to evaluate PD-L1 expression in advanced NSCLC appeared acceptable in association with relevant clinical outcomes after treatment with ICIs. A further prospective study with a larger sample size is required to confirm our findings.
- Subjects
NON-small-cell lung carcinoma; IMMUNE checkpoint inhibitors; LYMPH nodes; CELL death; LYMPHADENITIS; APOPTOSIS
- Publication
Surgery Today, 2020, Vol 50, Issue 9, p1049
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-020-01989-6