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- Title
A comprehensive evaluation of clinicopathologic characteristics, molecular features and prognosis in lung adenocarcinoma with solid component.
- Authors
Li, Jing; You, Wenjie; Zheng, Difan; Yan, Bei; Ma, Xiao; Pan, Yunjian; Zhang, Yang; Li, Yuan; Shen, Xuxia; Cheng, Xinghua; Sun, Yihua; Chen, Haiquan
- Abstract
Purpose: We have reported that solid predominant lung adenocarcinoma according to the IASLC/ATS/ERS classification was associated with poor prognosis. However, the correlation of solid component with clinicopathological, molecular features, and prognosis in all lung adenocarcinoma patients remains unexplored.Methods: Surgically resected lung adenocarcinomas were divided into three groups, solid predominant (solid component accounting for at least 50%), solid minor (solid component accounting for 5-45%) and solid negative. Patients’ clinicopathological characteristics, disease free survival (DFS), overall survival (OS) and molecular alterations, including <italic>EGFR, KRAS, FGFR</italic>, etc., were analyzed.Results: Of 1098 lung adenocarcinomas, 198 were solid predominant, 132 were solid minor, and 768 were solid negative. Solid positive patients, including solid predominant and solid minor, had significantly worse DFS (<italic>p</italic> < 0.0001) and OS (<italic>p</italic> < 0.0001) compared with solid negative group, so were solid minor patients (both <italic>p</italic> < 0.0001). Cox multivariate analysis revealed that solid positive pattern was an independent predictor for DFS [hazard ratio (HR) 1.495, 95% confidence interval (CI) 1.004-2.233; <italic>p</italic> = 0.034] and OS [HR 1.561, 95% CI 1.03-2.342; <italic>p</italic> = 0.016]. The frequency of <italic>FGFR</italic> fusions was significantly higher in solid positive lung adenocarcinomas than in solid negative group (1.5 vs. 0.3%, <italic>p</italic> = 0.048). The response rate to EGFR-tyrosine kinase inhibitors (TKIs) was 66.7% in <italic>EGFR</italic>-mutated solid positive patients after recurrence.Conclusions: This study represents the first comprehensive clinical investigation of solid component in lung adenocarcinomas, identifying solid positive pattern as an independent poor prognostic indicator in lung adenocarcinoma.
- Subjects
LUNG cancer; ADENOCARCINOMA; PROGRESSION-free survival; PROTEIN-tyrosine kinase inhibitors; MOLECULAR biology; PROGNOSIS
- Publication
Journal of Cancer Research & Clinical Oncology, 2018, Vol 144, Issue 4, p725
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-018-2588-6