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- Title
Predictive factors of vascular intima media thickness in HIV-positive subjects.
- Authors
M. Bongiovanni; M. Casana; P. Cicconi; M. Pisacreta; R. Codemo; M. Pelucchi; A. dArminio Monforte; T. Bini
- Abstract
: Background The predictive factors of intima media thickness (IMT) in the HIV-infected population are still poorly understood. : Patients and methods We studied three groups of subjects, aged 30–50 years, to find potential predictive factors of carotid and/or femoral thickening (IMT > 1 mm in at least one area): healthy controls (G1, n = 54), HIV-infected naive (G2, n = 53) and highly active antiretroviral treatment (HAART)-treated subjects (G3, n = 133). All the subjects underwent ultrasonography of the carotid and femoral vessels to evaluate IMT. : Results Demographic characteristics of the three groups were comparable, except for gender (G1 had a higher percentage of females) and lipid levels (higher in G3). A total of 115 subjects (47.9%) had carotid and/or femoral IMT: 26 in G1 (48.1%), 21 in G2 (39.6%) and 68 in G3 (51.1%). Independent predictive factors of carotid and/or femoral IMT were older age (OR: 2.81, 95% CI: 1.95–4.04, P < 0.01, for each additional 5 years), triglycerides ≥150 mg/dL (OR: 2.66, 95% CI: 1.27–5.57, P < 0.001), serum glucose ≥110 mg/dL (OR: 5.24, 95% CI: 1.02–27.05, P = 0.04), high homocysteinaemia (OR: 2.75, 95% CI: 1.17–6.46, P = 0.02) and high body mass index (OR: 1.10, 95% CI: 1–1.22, P = 0.05 for each additional unit); females had a lower risk (OR: 0.38, 95% CI: 0.18–0.79, P < 0.01 versus males). HAART use was not associated with IMT (OR: 0.64, 95% CI: 0.27–1.53, P = 0.32 and OR: 0.80, 95% CI: 0.30–2.13, P = 0.20 for G3 and G2 versus G1, respectively). : Conclusions This study demonstrates that traditional risk factors for cardiovascular diseases overshadow the role of HAART in determining premature vascular lesions.
- Subjects
BLOOD plasma; ULTRASONIC imaging; SERUM; BLOOD plasma substitutes
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2008, Vol 61, Issue 1, p195
- ISSN
0305-7453
- Publication type
Article