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- Title
Comparison of the antibacterial activities of ampicillin, ciprofloxacin, clarithromycin, telithromycin and quinupristin/dalfopristin against intracellular non-typeable Haemophilus influenzae.
- Authors
Ahrén, Irini Lazou; Karlsson, Eva; Forsgren, Arne; Riesbeck, Kristian; Ahrén, Irini Lazou
- Abstract
Non-typeable Haemophilus influenzae, which is a cause of disease in the upper and lower respiratory tract, can survive intracellularly in human epithelial cells and macrophages. We studied the in vitro activity of five antibiotics against intracellular non-typeable H. influenzae in human type II alveolar epithelial cells. The eukaryotic cells were loaded with bacteria, and extracellular bacteria were killed by gentamicin. After the cells were washed, antibiotics were added at concentrations of 0.12-64 mg/L for 18 h before the numbers of viable intracellular bacteria were determined. Of the antibiotics tested, ciprofloxacin and quinupristin/dalfopristin were the most potent agents, followed by clarithromycin and telithromycin. Ampicillin was not active against intracellularly localized, non-typeable H. influenzae.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2002, Vol 50, Issue 6, p903
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/dkf221