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- Title
Localization of [14C]amoxicillin in rat gastric tissue when administered with lansoprazole and clarithromycin.
- Authors
Endo, H.; Yoshida, H.; Ohmi, N.; Ohta, K.; Higuchi, S.
- Abstract
The gastric mucosal distribution of [14C]amoxicillin when administered to rats with or without lansoprazole and clarithromycin was investigated. After oral administration, the amount found in the gastric mucosa was higher than after iv administration. Co-administration of lansoprazole and clarithromycin had no apparent effect on the distribution pattern of [14C]amoxicillin within the deeper stomach layers. About 50-60% of the radioactivity in the gastric tissue was present in the mucosal layer, irrespective of the route of administration. Microautoradiograms of the gastric mucosa indicated that [14C]amoxicillin was distributed in both the mucous layer and surface epithelial cells following oral administration. [14C]amoxicillin was secreted mainly by surface epithelial cells after iv administration, although only in small quantities.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2001, Vol 48, Issue 6, p923
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/48.6.923