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- Title
Pharmacokinetics of a parenteral carbapenem, biapenem, in patients with end-stage renal disease and influence of haemodialysis.
- Authors
Nagashima, Satoru; Kozawa, Osamu; Otsuka, Takanobu; Kohno, Ken-ichi; Minamoto, Masahiko; Yokokawa, Masahiro; Kanamaru, Mitsutaka; Uematsu, Toshihiko; Nagashima, S; Kozawa, O; Otsuka, T; Kohno, K; Minamoto, M; Yokokawa, M; Kanamaru, M; Uematsu, T
- Abstract
The effects of haemodialysis on the pharmacokinetics of a carbapenem, biapenem, were evaluated in five patients with end-stage renal disease, who received 1 h iv infusions of 300 mg biapenem on both the days on and off 4 h haemodialysis. With haemodialysis, plasma biapenem exhibited two elimination phases, one during and the other after haemodialysis with half-lives of 1.16 ± 0.12 and 3.33 ± 0.91 h, respectively. Ninety percent of biapenem was removed from blood to dialysate. Without haemodialysis, plasma biapenem was mono-exponentially eliminated with a half-life of 4.35 ± 1.30 h.
- Subjects
ANTI-infective agents; CHRONIC kidney failure; HEMODIALYSIS; PHARMACOKINETICS; TIME; CARBAPENEMS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2000, Vol 46, Issue 5, p839
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/46.5.839