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- Title
Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia.
- Authors
Shand A; Nassar N; Von Dadelszen P; Innis S; Green T; Shand, A W; Nassar, N; Von Dadelszen, P; Innis, S M; Green, T J
- Abstract
<bold>Objective: </bold>To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes.<bold>Design: </bold>Prospective cohort study.<bold>Setting: </bold>Vancouver, British Columbia, Canada (49°N).<bold>Population: </bold>Women attending a specialist antenatal clinic because of clinical or biochemical risk factors for pre-eclampsia (n = 221).<bold>Methods: </bold>Serum 25OHD concentration measured between 10 and 20 weeks of gestation.<bold>Main Outcome Measures: </bold>Pre-eclampsia and composite adverse pregnancy outcomes.<bold>Results: </bold>Of the women, 78% were vitamin D insufficient (25OHD <75 nmol/l) and 53% were vitamin D deficient (25OHD <50 nmol/l). There was no difference in the rates of pre-eclampsia, gestational hypertension, preterm birth or composite adverse pregnancy outcomes by 25OHD concentration.<bold>Conclusions: </bold>Vitamin D deficiency and insufficiency were common in a group of women at high risk of pre-eclampsia; however, it was not associated with subsequent risk of an adverse pregnancy outcome.
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2010, Vol 117, Issue 13, p1593
- ISSN
1470-0328
- Publication type
journal article
- DOI
10.1111/j.1471-0528.2010.02742.x