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- Title
Fabrication of Poly (sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded doxorubicin Implants and in vitro characterization.
- Authors
Sreeharsha, Nagaraja; Hiremath, Jagadeesh G.; Al-Dhubiab, Bandar E.; Meravanige, Girish; Karnati, Ranjith Kumar; Attimarad, Mahesh; Nair, Anroop B.; Venugopal, Katharigatta N.; Morsy, Mohamed A.; Pottathil, Shinu; Khan, Saleemmulla; Molugulu, Nagashekhara
- Abstract
Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer. Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/w blank and drug-loaded implants for in vitro hydrolytic degradation. The drug present in the remaining sample was estimated. Results: The hydrolytic degradation rate of the 10% w/w (F2)-loaded implant was relatively low when compared with the 20% w/w (F3) implant. Discussion: In vitro drug release studies illustrated that the drug-release rate was faster in association with increasing amounts of doxorubicin in the implant.
- Subjects
BIOABSORBABLE implants; MELT spinning; X-ray diffraction
- Publication
Indian Journal of Pharmaceutical Education & Research, 2020, Vol 54, Issue 3, p826
- ISSN
0019-5464
- Publication type
Article
- DOI
10.5530/ijper.54.3.135