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- Title
ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF PHYLLOPHORA PSEUDOCERANOIDES (GMELIN) NEW. ET TAYL.
- Authors
TRIFAN, ADRIANA; SAVA, DACIANA; BUCUR, LAURA ADRIANA; MIHAI, COSMIN TEODOR; APROTOSOAIE, ANA CLARA; CIOANCĂ, OANA; HĂNCIANU, MONICA; MIRON, ANCA
- Abstract
The aim of the present study was to characterize and assess the in vitro antioxidant and cytotoxic activities of various solvent extracts from red alga Phyllophora pseudoceranoides. Bioactive compounds were extracted using solvents of different polarities. Total phenolic, flavonoid and carotenoid contents were also determined. Algal extracts displayed moderate 2,2-diphenyl-1-picryl-hydrazyl hydrate (DPPH) scavenging activity, with values ranging from 12.99 ± 0.23 to 46.00 ± 0.13 % at a concentration of 1.99 mg/mL; all extracts showed good scavenging activity against 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation, with EC50 values ranging from 0.12 ± 0.02 to 0.49 ± 0.02 mg/mL. All investigated extracts exhibited strong cytotoxic activities against HeLa cells. The antioxidant and cytotoxic effects of P. pseudoceranoides extracts suggest their possible use in the development of nutraceuticals and functional foods.
- Subjects
RED algae; THERAPEUTIC use of antioxidants; ANTINEOPLASTIC agents; BIOACTIVE compounds; HELA cells; THERAPEUTICS
- Publication
Farmacia, 2016, Vol 64, Issue 4, p502
- ISSN
0014-8237
- Publication type
Article