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- Title
Effects of niacin supplementation and different concentrate proportions on ruminal lipopolysaccharide concentration, immunological response and health of dairy cows.
- Authors
Rauls, Caroline; Meyer, Ulrich; Kersten, Susanne; von Soosten, Dirk; Höltershinken, Martin; Rehage, Jürgen; Breves, Gerhard; Dänicke, Sven
- Abstract
High concentrate proportions used in diets of high-yielding cows may lead to subacute ruminal acidosis, compromise the ruminal mucosal barrier and force transfer of lipopolysaccharides (LPS) with an eventual systemic inflammatory response. Because niacin (NA) increases performance and might exert anti-inflammatory effects, the present study investigates the effects of 60% vs. 30% concentrate proportions with or without 24 g niacin/cow/day on ruminal LPS content and indicators of inflammatory response. The experiment was carried out with four experimental groups, 60+NA, 60-, 30+NA, 30- and lasted from calving to week of lactation (WoL) 36. Ruminal LPS concentration was generally increased after feeding 60% concentrate diets and also modified by niacin, parity and WoL. Also total leukocytes, hematocrit, fibrinogen and aspartat-aminotransferase were influenced in an interactive manner, while glutamate dehydrogenase and gamma-glutamyl transferase activities were elevated due to the 60% concentrate proportion. The stimulation index of peripheral blood mononuclear cells was subjected to a 2-way interactive effect of concentrate and niacin feeding, being highest in 30- groups (cows and heifers). In conclusion, long-term feeding of high-energy diets increases the LPS load of the rumen and compromises the liver.
- Subjects
NIACIN; FEED additives; LIPOPOLYSACCHARIDES; IMMUNE response; CATTLE feeding &; feeds; COWS; ANIMAL health
- Publication
Landbauforschung, 2017, Vol 67, Issue 1, p33
- ISSN
2194-3605
- Publication type
Article
- DOI
10.3220/LBF1490961559000