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- Title
Effect of resistance exercise training on plasma neurofilaments in multiple sclerosis: a proof of concept for future designs.
- Authors
Mulero, Patricia; Maroto-Izquierdo, Sergio; Redondo, Natán; Gonzalo-Benito, Hugo; Chavarría-Miranda, Alba; Calvo, Hugo; Cabero, María I.; Hernandez, Marita; Nieto, María Luisa; Tellez, Nieves
- Abstract
Multiple sclerosis (MS) is a dysimmune and neurodegenerative disease of the central nervous system that continues to be one of the main causes of non-traumatic disability in young people despite the recent availability of highly effective drugs. Exercise-based interventions seem to have a positive impact on the course of the disease although pathophysiological mechanisms responsible for this benefit remain unclear. This is a longitudinal study to examine the effects of a short-term training program on neurofilament plasma levels, a biomarker of axonal destruction, measured using the ultrasensitive single molecule array (SiMoA). Eleven patients completed a 6-week supervised resistance-training program of 18 sessions that consisted of 3 sets of 8–10 repetitions of 7 exercises. Median plasma neurofilament levels significantly decreased from baseline (6.61 pg/ml) to 1 week after training intervention (4.44 pg/ml), and this effect was maintained after 4 weeks of detraining (4.38 pg/ml). These results suggest a neuroprotective effect of resistance training in this population and encourage us to investigate further the beneficial impact of physical exercise and to emphasize the importance of lifestyle in MS.
- Subjects
EXERCISE therapy; RESISTANCE training; MULTIPLE sclerosis; CYTOPLASMIC filaments; YOUNG adults
- Publication
Neurological Sciences, 2023, Vol 44, Issue 11, p3997
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-023-06896-5