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- Title
Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit).
- Authors
Ustun, Celalettin; Morgan, Elizabeth; Moodie, Erica E. M.; Pullarkat, Sheeja; Yeung, Cecilia; Broesby‐Olsen, Sigurd; Ohgami, Robert; Kim, Young; Sperr, Wolfgang; Vestergaard, Hanne; Chen, Dong; Kluin, Philip M.; Dolan, Michelle; Mrózek, Krzysztof; Czuchlewski, David; Horny, Hans‐Peter; George, Tracy I.; Kristensen, Thomas Kielsgaard; Ku, Nam K.; Yi, Cecilia Arana
- Abstract
Abstract: Background: Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods: Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results: Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions: I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score).
- Subjects
ACUTE myeloid leukemia; HEMATOPOIETIC stem cell transplantation; CANCER relapse; CARRIER proteins; PROGNOSIS; DISEASE risk factors
- Publication
Cancer Medicine, 2018, Vol 7, Issue 9, p4447
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.1733