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- Title
Type IV hypersensitivity to vitamin K.
- Authors
Sommer, Sabine; Wilkinson, S. Mark; Peckham, Daniel; Wilson, Caroline
- Abstract
The day after intramuscular injection of vitamin K1 (phytomenadione) into her thigh, a 27-year-old-woman with normal liver function developed a relapsing and remitting eczematous reaction localized to the injection site, and later a further eczematous reaction under an adhesive dressing (Duoderm® ). On patch testing, she was positive to vitamin K1 and cross-reacted to vitamin K4 ; she was also positive to colophonium and to ester gum rosin, the dressing adhesive. Recurrent angioedema persisted for several months and, 2 years later, symptoms were still occurring over the injection sites. Structure-activity relationships among vitamin K allergens are discussed.
- Subjects
VITAMIN K; ALLERGIES
- Publication
Contact Dermatitis (01051873), 2002, Vol 46, Issue 2, p94
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1034/j.1600-0536.2002.460206.x