We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Increased frequency of CD4<sup>+</sup>CD57<sup>+</sup> senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance.
- Authors
Youn, Jong-Chan; Jung, Min Kyung; Yu, Hee Tae; Kwon, Ji-Soo; Kwak, Jeong-Eun; Park, Su-Hyung; Kim, In-Cheol; Park, Myung-Soo; Lee, Sun Ki; Choi, Suk-Won; Han, Seongwoo; Ryu, Kyu-Hyung; Kang, Seok-Min; Shin, Eui-Cheol
- Abstract
Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57+ T cells in the CD4+ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4+CD57+ T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4+CD57− T cell population. Furthermore, the frequency of CD4+CD57+ T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4+CD57+ senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF.
- Subjects
T cells; PATIENTS; HEART failure; MEDIATORS (Persons); CARDIOVASCULAR system
- Publication
Scientific Reports, 2019, Vol 9, Issue 1, pN.PAG
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-019-49332-5