We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Insights into the Age Dependency of Compositional MR Biomarkers Quantifying the Health Status of Cartilage in Metacarpophalangeal Joints.
- Authors
Frenken, Miriam; Radke, Karl Ludger; Schäfer, Emilia Louisa Ernestine; Valentin, Birte; Wilms, Lena Marie; Abrar, Daniel Benjamin; Nebelung, Sven; Martirosian, Petros; Wittsack, Hans-Jörg; Müller-Lutz, Anja
- Abstract
(1) Background: We aim to investigate age-related changes in cartilage structure and composition in the metacarpophalangeal (MCP) joints using magnetic resonance (MR) biomarkers. (2) Methods: The cartilage tissue of 90 MCP joints from 30 volunteers without any signs of destruction or inflammation was examined using T1, T2, and T1ρ compositional MR imaging techniques on a 3 Tesla clinical scanner and correlated with age. (3) Results: The T1ρ and T2 relaxation times showed a significant correlation with age (T1ρ: Kendall-τ-b = 0.3, p < 0.001; T2: Kendall-τ-b = 0.2, p = 0.01). No significant correlation was observed for T1 as a function of age (T1: Kendall-τ-b = 0.12, p = 0.13). (4) Conclusions: Our data show an increase in T1ρ and T2 relaxation times with age. We hypothesize that this increase is due to age-related changes in cartilage structure and composition. In future examinations of cartilage using compositional MRI, especially T1ρ and T2 techniques, e.g., in patients with osteoarthritis or rheumatoid arthritis, the age of the patients should be taken into account.
- Subjects
KENDALL (Fla.); METACARPOPHALANGEAL joint; CARTILAGE; MAGNETIC resonance imaging; BIOMARKERS; MAGNETIC resonance
- Publication
Diagnostics (2075-4418), 2023, Vol 13, Issue 10, p1746
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics13101746