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- Title
Beyond the Cardiorenal Syndrome: Pathophysiological Approaches and Biomarkers for Renal and Cardiac Crosstalk.
- Authors
Buliga-Finis, Oana Nicoleta; Ouatu, Anca; Badescu, Minerva Codruta; Dima, Nicoleta; Tanase, Daniela Maria; Richter, Patricia; Rezus, Ciprian
- Abstract
Cardiorenal syndrome encompasses complex multifactorial facets and carries significant morbidity and mortality worldwide. The bi-directional relationship between the heart and kidneys, where dysfunction in one organ worsens the function of the other, has been the leading motor for research in the last few years. In the pathophysiological process, small noncoding RNAs, epigenetics, vascular growth factors, oxidative stress, hemodynamic factors, and biomarkers play a pivotal role in the development of cardiorenal syndrome. It is therefore important to elucidate all the mechanisms in order to provide diagnostic and treatments tools. This review summarizes the hemodynamic and non-hemodynamic pathways along with biomarkers that could be the next target for diagnosis, treatment, and prognosis in cardiorenal syndrome.
- Subjects
CARDIO-renal syndrome; HEPATORENAL syndrome; NON-coding RNA; BIOMARKERS; GROWTH factors
- Publication
Diagnostics (2075-4418), 2022, Vol 12, Issue 4, p773
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics12040773