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- Title
Molecular Epidemiology and Outcome ofHelicobacter pyloriInfection in Thailand: a Cultural Cross Roads.
- Authors
Ratha-Korn Vilaichone; Mahachai, Varocha; Tumwasorn, Somying; Jeng-Yih Wu; Graham, David Y.; Yamaoka, Yoshio
- Abstract
Thailand is at the cultural cross roads between East and South Asia. It has been suggested that this is also the region where the predominantHelicobacter pylori(H. pylori) genotype changes from East Asian to South Asian.We compared the molecular epidemiology and outcome ofH. pyloriinfections among different ethnic groups in Thailand (Thai, Thai-Chinese and Chinese).H. pyloriisolates were genotyped by polymerase chain reaction based oncagA,cagright end junction andvacAgenotypes.Ninety-eight isolates from 38 ethnic Thai, 20 ethnic Chinese and 40 Thai-Chinese were categorized into East Asian (45%), South/Central Asian (26%), Western (1%) or mixed type (29%). The East Asian genotype was the most common among Chinese (85%) and Thai-Chinese (55%) (p < .01 compared to ethnic Thai). The ethnicity of the mother among mixed Thai-Chinese marriages predicted the genotype of the child'sH. pylori(e.g. when the mother was Chinese, 84% had East Asian type vs. 29% when the mother was Thai) (p < .001). Gastric cancer was common among ethnic Chinese with East Asian genotype (e.g. all Chinese with gastric cancer or peptic ulcer disease had East Asian genotype, whereas only 40% of Chinese with gastritis had this genotype).Immigration, intermarriage and the variety ofH. pylorigenotypes in Thailand suggest that Thailand is an ideal site for epidemiological studies attempting to relateH. pylorigenotypes and host factors to outcome. Our data also support the hypothesis that the primary caretaker of the children is most likely the source of the infection.
- Subjects
THAILAND; MOLECULAR epidemiology; HELICOBACTER pylori infections; BACTERIAL diseases; GENOTYPE-environment interaction; POLYMERASE chain reaction
- Publication
Helicobacter, 2004, Vol 9, Issue 5, p453
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1111/j.1083-4389.2004.00260.x