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- Title
Evaluation of treatment for gastro-oesophageal reflux disease with a proton pump inhibitor, and relationship between gastro-oesophageal reflux disease and Helicobacter pylori infection in Japan.
- Authors
Muramatsu, A.; Azuma, T.; Okajima, T.; Ohtani, M.; Dojo, M.; Yamazaki, Y.; Kuriyama, M.
- Abstract
: Effective therapy for gastro-oesophageal reflux disease (GERD) is associated with improvement in health-related quality of life. It remains unclear whether Helicobacter pylori infection protects against GERD. : We evaluated the relationship between GERD and H. pylori, and whether the health-related quality of life score improved after medical treatment. : We enrolled 151 outpatients with upper abdominal symptoms; 81 patients received omeprazole 20 mg/day for 2 weeks. Health-related quality of life was assessed using the Gastrointestinal Symptom Rating Scale (GSRS) and the Psychological General Well-Being (PGWB) index. H. pylori infection was diagnosed by serum antibody or endoscopy and the relationship between GERD and H. pylori was evaluated. : In GERD patients, the mean GSRS score improved from 2.20 to 1.67 following treatment ( P < 0.01). The mean GSRS reflux symptom score improved from 2.96 to 1.67 ( P < 0.01). The mean PGWB score improved from 96.36 to 107.34 ( P < 0.01). All scores in GERD patients significantly improved compared with non-GERD patients. The H. pylori-positive ratio was 66.15% in GERD patients and 65.21% in non-GERD patients ( P = 0.94). : Health-related quality of life is useful for evaluation of proton pump inhibitor treatment in GERD. The presence of H. pylori was not associated with the prevalence of GERD.
- Subjects
JAPAN; HELICOBACTER pylori infections; GASTROESOPHAGEAL reflux; PROTON pump inhibitors; MEDICAL care; ENDOSCOPY
- Publication
Alimentary Pharmacology & Therapeutics, 2004, Vol 20, p102
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2004.01983.x