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- Title
Is autonomic dysfunction a necessary condition for chronic peptic ulcer formation?
- Authors
Nomura, M.; Yukinaka, M.; Miyajima, H.; Nada, T.; Kondo, Y.; Okahisa, T.; Shibata, H.; Okamura, S.; Honda, H.; Shimizu, I.; Saito, K.; Oki, T.; Nakaya, Y.; Ito, S.
- Abstract
The relationship between 1/ƒ fluctuation of the heart rate variability and Helicobacter pylori infection was evaluated, in order to clarify whether autonomic nervous dysfunction is a necessary condition for chronic peptic ulcer formation. For the normal group, the absolute slope of the regression line during daytime and night-time were 0.53±0.16 and 1.05±0.18, respectively. For the peptic ulcer group, the corresponding values during daytime and night-time were 0.94±0.15 and 1.84±0.18, respectively. The mean value of the cosine curve was 0.76±0.23 in the normal group and 1.12±0.25 in the peptic ulcer group. Thus, these values were significantly higher for the latter group than for the former group (P<0.05). No statistically significant difference in H. Pylori infection between the two groups was observed. Autonomic nervous dysfunction as well as H. pylori infection appears to be a necessary condition for chronic peptic ulcer formation.
- Subjects
HEART beat; HELICOBACTER pylori infections; REGRESSION analysis; PEPTIC ulcer
- Publication
Alimentary Pharmacology & Therapeutics, 2000, Vol 14, p82
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1046/j.1365-2036.2000.014s1082.x