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- Title
Transdermal Study of Curcumin Solid Dispersion Microneedles in vitro.
- Authors
Jiao LUO; Cong WANG; Yuping MA; Shengqian TAN; Jiayi DING; Lili HE
- Abstract
[Objectives] To investigate the in vitro transdermal effect of curcumin solid dispersion needles prepared with povidone K 30 (PVP K30), polyethylene glycol 6000 (PEG 6000) and poloxamer 188 (block polyether F68, poloxamer 188, F68) as carrier matrix, respectively. [Methods] Vertical Franz diffusion cell and HPFC method were used to detect the cumulative penetration and skin retention of the microneedles within 12 h. [Results] Within 12 h, the cumulative penetration of PVP K30 microneedles was as high as 7.098 µg/cm², and the skin retention reached 35.28 µg/cm; PEG 6000 and poloxamer 188 microneedles all showed good transdermal effect; while normal curcumin solid dispersion (control) had no obvious transdermal effect. [Conclusions] The transdermal penetration of curcumin is improved after prepared in to solid dispersion microneedles, and among different matrixes, PVP K30 is the best choice.
- Subjects
CURCUMIN; DISPERSION (Chemistry); POLYETHYLENE glycol; SOLIDS; POVIDONE
- Publication
Medicinal Plant, 2021, Vol 12, Issue 2, p6
- ISSN
2152-3924
- Publication type
Article
- DOI
10.19600/j.cnki.issn2152-3924.2021.02.003