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- Title
Effect of Different Levels of Niacin on Serum Biochemical Parameters, Antioxidant Status, Cytokine Levels, Inflammatory Gene Expression and Colonic Microbial Composition in Weaned Piglets.
- Authors
Wang, Zhaobin; Yi, Zhenfeng; Wang, Qiye; Yin, Lanmei; Li, Jun; Xie, Junyan; Yang, Huansheng; Yin, Yulong
- Abstract
Simple Summary: Niacin, an essential vitamin in weaned pig diets, plays an important role in regulating anti-inflammatory effects and gut health. This study aimed to investigate the effects of niacin supplementation in newly weaned piglets' diets on inflammation resistance, immunity enhancement, intestinal antioxidant status, and intestinal microbial composition. Studies have found that niacin can significantly improve immunity, antioxidant status and anti-inflammatory effects in newly weaned piglets, better relieve stress damage caused by weaning, improve colonic microbial diversity, and promote intestinal health. Niacin plays an important role in regulating the gut health of weaned piglets. In this study, 48 25-day-old weaned piglets (7.9 ± 0.20 kg) produced by 14 sows (3 to 4 piglets per sow) were randomly divided into 4 groups with 6 replicates in each group and 2 piglets in each replicate. Each group was fed diets supplemented with 22.5 (N1), 30 (N2), 45 (N3), and 75 (N4) mg/kg of niacin, respectively. Samples were taken at 7 and 14 d, respectively. The study shows that changes in niacin levels significantly affected the content of IgG and IgM in the serum (p < 0.05). Niacin had a significant effect on antioxidant parameters such as MDA, T-SOD, and CuZn-SOD in the jejunal mucosa of weaned piglets (p < 0.05). Moreover, significant differences were observed in the expression of cytokines such as TGF-β, TNF-α, and COX2 in the jejunal mucosa (p < 0.05). The 16S rRNA sequencing analysis showed that there were significant differences in the colonic species composition, which were also accompanied by changes in the isovaleric acid content (p < 0.05). In conclusion, an appropriate increase in niacin dose based on NRC (2012) has an important role in improving the antioxidant status of weaned piglets, alleviating intestinal inflammation in piglets, improving immunity, and regulating the structure of the microbiota.
- Subjects
NIACIN; OXIDANT status; PIGLETS; GENE expression; MICROBIAL diversity; ANIMAL weaning; MATERNALLY acquired immunity; GUT microbiome
- Publication
Animals (2076-2615), 2022, Vol 12, Issue 21, p3018
- ISSN
2076-2615
- Publication type
Article
- DOI
10.3390/ani12213018