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- Title
IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo.
- Authors
Haeberlein, Simone; Sebald, Heidi; Bogdan, Christian; Schleicher, Ulrike
- Abstract
Activation of NK cells is a hallmark of infections with intracellular pathogens. We previously showed that the protozoan parasite Leishmania infantum triggered a rapid NK-cell response in mice that required TLR9-positive myeloid DC and IL-12, but no IFN-α/β. Here, we investigated whether IL-15 or IL-18 mediate the activity of IL-12 or function as independent activators of NK cells. In contrast to earlier studies that described IL-15 as crucial for NK-cell priming in response to TLR ligands, the expression of IFN-γ, FasL, perforin and granzyme B by NK cells in L. infantum-infected mice was completely preserved in the absence of IL-15, whereas the proliferative capacity of NK cells was lower than in WT mice. IFN-γ secretion, cytotoxicity and FasL expression of NK cells from infected IL-18
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 6, p1708
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200939988