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- Title
Mycobacterium tuberculosismacrophage interaction: Molecular updates.
- Authors
Haotian Bo; Moure, Ulrich Aymard Ekomi; Yuanmiao Yang; Jun Pan; Li Li; Miao Wang; Xiaoxue Ke; Hongjuan Cui
- Abstract
Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB), remains a pathogen of great interest on a global scale. This airborne pathogen affects the lungs, where it interacts with macrophages. Acidic pH, oxidative and nitrosative stressors, and food restrictions make the macrophage's internal milieu unfriendly to foreign bodies. Mtb subverts the host immune system and causes infection due to its genetic arsenal and secreted effector proteins. In vivo and in vitro research have examined Mtb-host macrophage interaction. This interaction is a crucial stage in Mtb infection because lung macrophages are the first immune cells Mtb encounters in the host. This review summarizes Mtb effectors that interact with macrophages. It also examines how macrophages control and eliminate Mtb and how Mtb manipulates macrophage defense mechanisms for its own survival. Understanding these mechanisms is crucial for TB prevention, diagnosis, and treatment.
- Subjects
MYCOBACTERIUM tuberculosis; MOLECULAR interactions; MYCOBACTERIUM; IMMUNE system; FOREIGN bodies; TUBERCULOSIS
- Publication
Frontiers in Cellular & Infection Microbiology, 2023, Vol 13, p1
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2023.1062963