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- Title
Positive Mixed lymphocyte Culture Test Result Due to HLA-DP Mismatch.
- Authors
Ayna, Tülay K; Tozkir, Hilmi; Çiftçi, Hayriye S; Gürkan, Hakan; Tekgündüz, Emre; Algünes, Çetin; Gürtekin, Mehmet; Çarin, Mahmut
- Abstract
Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the related recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DQ but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mismatch was responsible for the increased proliferation values in MLC test.
- Publication
Balkan Medical Journal, 2011, Vol 28, Issue 2, p224
- ISSN
2146-3123
- Publication type
Journal Article