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- Title
Trends in LDL-C and Non-HDL-C Levels with Age.
- Authors
Peng Zhang; Qian Su; Xiaomiao Ye; Ping Guan; Chengjun Chen; Yanwen Hang; Jian Dong; Zhongjie Xu; Wei Hu
- Abstract
Understanding how blood lipid levels change with age in the general population is a precondition to defining dyslipidemia. To explore age-related trends in LDL-C and non-HDL-C levels in the general population, a large-scale cross-sectional study with 49,201 males and 35,084 females was adopted. Trends of non- HDL-C and LDL-C levels were plotted against each age (18 to 85 years old, one-year increments); the trends, as well as the influence of confounding factors on the trends, were validated and adjusted by linear regression modeling. The trajectory of LDL-C and non-HDL-C levels by age displayed a nonlinear correlation trend. Further multivariate linear regression modeling that incorporated sex-specific age phases showed that age was positively associated with LDL-C and non-HDL-C levels, with coefficients of 0.018 and 0.031, respectively, in females aged ≥18 to ≤56 years and negatively associated with LDL-C and non-HDL-C levels, with coefficients of -0⋅013 and -0.015, respectively, in females aged ≥57 years. The LDL-C and non-HDL-C levels increased with age in males ≥18 to ≤33 years of age, with coefficients of 0.025 and 0.053, respectively; the lipid levels plateaued at ≥34 to ≤56 years of age and subsequently decreased in those ≥57 years of age, with coefficients of -0.008 and -0.018, respectively. In contrast, pooled analyses without age stratification concealed these details. In conclusion, fluctuating increasing and decreasing lipid levels occurred with phases of aging in both sexes. Well-grounded age stratification is necessary to improve lipid-related pathophysiological studies.
- Subjects
BLOOD lipids; DYSLIPIDEMIA; AGE factors in disease; LOW density lipoproteins; PATHOLOGICAL physiology
- Publication
Aging & Disease, 2020, Vol 11, Issue 5, p1046
- ISSN
2152-5250
- Publication type
Article
- DOI
10.14336/AD.2019.1025